No. 17 Iowa State will play Kansas on Saturday at 2:30 p.m. at Arrowhead Stadium in Kansas City, Missouri.
The Cyclones will be trying to bounce back from a surprise loss to Texas Tech and remain in contention for playing in the conference title game.
They trail unbeaten BYU and are tied with Colorado in the Big 12 standings.
Kansas had last week off following a last-second loss to rival Kansas State.
The Cyclones are 2-6 and need to win out to reach a bowl game for the third consecutive season.
The game will be broadcast on Fox Sports 1.