Police said they received a report of a man being shot just before 11:30 p.m. near a plaza on York Boulevard at East Beaver Creek Road.
Responding officers said they arrived at a parking lot to find an adult male with multiple gunshot wounds.
The victim was transported to hospital where he was pronounced dead, police said.
Investigators believe the shooting to be a targeted attack and say there is no threat to public safety at this time.
The scene of the crime has many busy restaurants and nightclubs nearby, and York police are asking any potential witnesses to come forward with information.